This study aimed to compare the effectiveness of Celebrex with the use of a COX-2 inhibitor in an acute coronary syndrome (ACS) trial. It was conducted in a population of patients with a history of coronary artery disease (CAD) or coronary artery bypass graft (CABG). The primary outcome was a composite of death and hospitalization for ACS.
We recruited a cohort of patients aged 20 to 60 years with a history of coronary artery disease (CAD) or CABG who had a diagnosis of an ACS. The Cox-2 inhibitor celecoxib was used as the COX-2 inhibitor. The secondary outcome was the composite of death and hospitalization for ACS.
The Cox-2 inhibitor celecoxib was a superior treatment for the treatment of ACS in a large prospective cohort (n = 8). In the overall cohort, there was a statistically significant decrease in the composite of death and hospitalization for ACS between celecoxib and placebo groups, but no difference in the composite of hospitalization for ACS between celecoxib and placebo groups. The celecoxib group had a significantly lower composite of death and hospitalization for ACS compared to the placebo group (n = 9).
Celecoxib significantly improved the patient's ability to walk with no significant difference between celecoxib and placebo groups. However, patients in the celecoxib group required longer time to reach the physical examination and required hospitalization for ACS. The celecoxib group had significantly lower composite of death and hospitalization for ACS compared to the placebo group. In addition, the celecoxib group had significantly lower composite of death and hospitalization for ACS compared to the placebo group.
Celecoxib is a superior treatment for the treatment of ACS in a large prospective cohort (n = 8) compared with the placebo. The results of this study showed that the COX-2 inhibitor celecoxib can be an effective treatment in the treatment of ACS. Celecoxib has a favorable safety profile and has a low risk of serious cardiovascular events.
Citation:Varghese ME, Cai JH, et al. (2021) Comparative effectiveness of celecoxib with the use of a COX-2 inhibitor in an acute coronary syndrome (ACS) trial. PLoS ONE 18(6): e014889. https://doi.org/10.1371/journal.pone.014889
Editor:Y. M. Kim, Hong Kong University of Science and Technology, Hong Kong
Received:January 15, 2021;Accepted:December 6, 2021;Published:December 10, 2021
Copyright:© 2021 Varghese et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper.
Funding:This work was supported by the National Natural Science Foundation of China (grant number 81172584), and was supported by the National Key Research and Development Research Institute of China (grant number 2018BZZ09). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
COX-2 inhibitors are widely used in the management of heart failure. In a population of patients with an established diagnosis of cardiovascular disease, COX-2 inhibitors are preferred over nonselective NSAIDs due to their favorable safety and tolerability. However, the use of COX-2 inhibitors carries a risk of gastrointestinal toxicity including ulceration, bleeding, and perforation. NSAIDs are a class of drugs that cause gastrointestinal toxicity when administered for the first time in patients with coronary artery disease (CAD).
Celebrex, a COX-2 inhibitor, has shown an efficacy of up to 81% with a low incidence of cardiovascular side effects. The most common adverse effects reported with celecoxib include gastrointestinal disorders, such as nausea, vomiting, diarrhea, and abdominal pain.
Celebrex 200mg capsules are a valuable tool for treating various pain conditions, including arthritis. These capsules contain Celebrex 200mg, a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins, a group of chemicals in the body that cause pain. This reduction in prostaglandins causes inflammation and pain, helping patients to maintain their mobility and overall comfort. Celebrex is frequently prescribed to treat conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Additionally, Celebrex is also used to treat pain associated with sprains and strains. It's important to note that Celebrex is only approved for short-term use and can take several weeks to improve symptoms. Patients should also be aware of potential side effects such as gastrointestinal upset, which can occur with prolonged use or in some cases with low-dose Celebrex. Additionally, individuals with pre-existing kidney or liver disease should also be cautious when using Celebrex, as the medication may not be suitable for those with existing liver or kidney impairment. Additionally, Celebrex is not intended to be used for the treatment of other conditions, such as arthritis or pain, but instead should be used with caution. It is important to note that Celebrex does not cure the underlying condition, but it helps alleviate symptoms by reducing inflammation and promoting the growth of new cells in the body. However, it is important to consult with a healthcare provider to ensure that Celebrex is the right choice for you and to determine the best course of treatment for your pain or inflammation.
VIDEOCelebrex 200mg Capsules provide a convenient and reliable way to treat pain and inflammation. By using this medication, patients can experience improved mobility and comfort, reduce stiffness, and relieve symptoms such as pain and swelling. This makes Celebrex a valuable tool in the medical community for patients suffering from conditions such as arthritis and pain. Additionally, the capsule also offers a low-maintenance option that may be suitable for some patients, but it's important to consult with a healthcare provider to determine the best course of treatment for your condition. By following the sig on the label, patients can maximize the benefits of this medication while minimizing potential side effects.
Celebrex 200mg Capsules are designed to help patients manage their pain and inflammation.
Celebrex 200mg capsules provide effective pain relief for patients suffering from arthritis and pain.
Celebrex 200mg capsules contain celecoxib, a non-steroidal anti-inflammatory drug (NSAID).
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Celebrex (celecoxib) is a selective estrogen receptor modulator (SERM) in the treatment of breast cancer. research shows that Celebrex is more effective in reducing the risk of recurrence in postmenopausal women with early breast cancer, compared to tamoxifen. Celecoxib is also approved for the treatment of osteoporosis in postmenopausal women. Celecoxib is also approved for the treatment of osteoporosis in postmenopausal women with no apparent bone loss. Celebrex is also approved for the treatment of osteoporosis in postmenopausal women with no apparent bone loss. Celecoxib is also approved for the treatment of early breast cancer in postmenopausal women with early-stage breast cancer, compared to tamoxifen. In October 2020, Healthylife announced that it had licensed this drug for the treatment of advanced breast cancer in postmenopausal women. This approval was made possible by the significant sales opportunity generated by the FDA’s approval of Celebrex for the treatment of advanced breast cancer in postmenopausal women.Celecoxib is a non-steroidal aromatase inhibitor. It is used to treat symptoms of advanced breast cancer such as slow or irregular growths, nipple discharge or pain, tenderness, swelling, or discomfort. Celecoxib can be used in the treatment of advanced breast cancer in postmenopausal women who have no established superior local control. Celecoxib is also used in the treatment of breast cancer in hormone receptor positive early or advanced breast cancer that has spread to other parts of the body.
Celecoxib is a SERM approved for the treatment of advanced breast cancer in postmenopausal women with early breast cancer. Celecoxib is also approved for the treatment of advanced breast cancer in postmenopausal women with no established superior local control. Celecoxib is also approved for the treatment of breast cancer in hormone receptor positive early or advanced breast cancer that has spread to other parts of the body.
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Celecoxib (celecoxib) is a medication used for the treatment of pain and inflammation associated with osteoporosis. Celecoxib belongs to a class of drugs known as estrogen modulators. Celecoxib is used to relieve symptoms of osteoporosis, such as slow or irregular growths, nipple discharge, and pain. Celecoxib is also used in the treatment of cancer in hormone receptor positive early or advanced breast cancer that has spread to other parts of the body.Celecoxib is a prescription drug. This medicine may be used for other purposes; not life.
Celebrex (celecoxib) is a prescription medicine prescribed for the treatment of serious pain associated with osteoarthritis, rheumatoid arthritis (RA), ankylosing spondylitis, ankylosing spondylitis, acute pain and acute inflammation of the spine. Celebrex can relieve symptoms such as fever, sore throat, swollen glands, headache, muscle pain and joint pain. Celebrex belongs to a class of drugs known as COX-2 inhibitors. These drugs work by blocking the activity of the enzyme COX-2, which is involved in the synthesis of proteins responsible for inflammation. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that is used to treat arthritis, pain, and other symptoms of arthritis such as joint pain and stiffness. Celebrex can also be used to relieve pain and reduce the severity of pain associated with a variety of acute or chronic diseases such as osteoarthritis, ankylosing spondylitis, rheumatoid arthritis, ankylosing spondylitis, and ankylosing spondylitis. Celebrex is available in capsule form and is typically taken once or twice a day. It can be taken with or without food. The recommended dose of Celebrex is 200 mg once a day, divided into two equal doses. Do not take more than one dose of Celebrex per day. The maximum daily dose of Celebrex is 1200 mg. It is important to note that Celebrex should not be used by people with a history of cardiovascular diseases, liver or kidney problems, or who have a history of heart attacks or strokes. Before using Celebrex, tell your doctor if you have kidney disease or are pregnant or plan to become pregnant. Also, tell your doctor if you are breastfeeding. The doctor may prescribe Celebrex for a certain number of days per month. Be sure to tell the doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and nutritional supplements, and herbal products. If you have any questions about this medication, tell the doctor or pharmacist right away. Celebrex is available only with a doctor’s prescription. If you are pregnant or breastfeeding, talk with your doctor or pharmacist about other treatment options, such as surgery or hormone replacement therapy. If you have heart, liver or kidney disease, your doctor will recommend that you take Celebrex along with a low dose of a specific anti-inflammatory medicine such as ibuprofen or naproxen.
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